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Saturday, November 14, 2020

Single 'polypill' found to cut heart attacks, stroke, but is it worth it?

Closer to the “exercise pill?” The idea behind the “exercise pill“ is to re-create the salutary biochemical effects of exercise. Based on the work of biologist Ronald Evans from the Salk Institute, exercise mimetic pharmacotherapy (so-called "exercise pill") targets genetic switches (like PPAR-gamma and PPAR-delta for adipose tissue regulation). Evans is well known in the field for having discovered a family of hormone receptors that act as genetic switches--PPAR-gamma and PPAR-delta--for adipose tissue regulation. That discovery lead to the development of the drug GW1516 (by Glaxo Wellcome, now GlaxoSmithKline). It was made to change cholesterol levels and to try to increase HDL cholesterol (which is typically increased by exercise). The four-drug regimen mentioned in this article all target, in part, benefits derived from exercise. We have been inching towards a “exercise pill“ which would trick the body into thinking we are exercising. Of course, we can get up and go for a walk too. 🙂
from Rajesh Harrykissoon, MD

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