I've been keeping an eye on this type of research for some years now. Much of the endorsement for caloric restriction diets is predicated on modulation of insulin like growth factor (IGF) with greatest evidence from rodent models and sparse correlating evidence of similar effect in humans. The author's assertion that “hunter-gatherer humans [who] rarely, if ever, suffer from obesity, diabetes, and cardio-vascular disease” may not be because of diet solely. According to historical mortality levels from the Encyclopaedia of Population (2003), average life expectancy for prehistoric humans was estimated at just 20 – 35 years. The reasons early humans may not have suffered from obesity, diabetes and cardiovascular disease may be because we were cut down at an early age due to malnutrition, infection and trauma. That is, we did not live long enough to develop cancer, heart disease or other diseases.
from Rajesh Harrykissoon, MD Fasting regimes such as the '5:2' diet could help the body guard against diseases including cancer, diabetes and Alzheimer's, according to a new study. The common eating pattern in modern societies http://ift.tt/1CZ55zC