Harry J. de Koning, M.D., from the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues used data from five independent models to examine the benefits and harms of CT screening for lung cancer among those aged 45 to 90 years. A total of 576 scenarios with varying eligibility criteria and screening intervals were included. The most advantageous strategy, including screening for 55- to 80-year-old ever smokers with 30 or more pack-years exposure, would lead to 50 percent of cases being detected at stage I/II and a 14 percent reduction in lung cancer mortality.
Based on the findings, the USPSTF recommends annual lung cancer screening with low-dose CT for asymptomatic adults aged 55 to 80 years with a 30 pack-year history and who currently smoke or quit within the last 15 years. Once a person has not smoked for 15 years or develops a health issue that limits life expectancy or the ability to undergo curative lung surgery, screening should be discontinued.
"It's clear that the longer and the more a person smokes, the greater their risk is for developing lung cancer," Michael LeFevre, M.D., M.S.P.H., Task Force co-vice chair, said in a statement. "When clinicians are determining who would most benefit from screening, they need to look at a person's age, overall health, how much the person has smoked, and whether the person is still smoking or how many years it has been since the person quit."
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